• A plant alkaloid (Autumn crocus, Colchicum autumnale) • MOA: binds to tubulin, a microtubular protein, causing its depolymerization (disrupts cellular functions, such as mobility of granulocytes); blocks cell division by binding to mitotic spindle ANTI-INFLAMMATORY SPECIFIC FOR GOUT USUALLY EFFECTIVE WITHIN 12 HOURS FROM ADMINISTRATION (should be administered within 36 hrs of onset of attack to be effective) •N & V, abdominal pain, diarrhea •Chronic administration: myopathy, neutropenia, aplastic anemia, alopecia