General Pathology: Healing + Repair
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General Pathology: Healing + Repair - Details
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🇬🇧 | 🇬🇧 |
Regrowth of original tissue | Regeneration |
Smooth Muscle + connective tissue | Myofibroblasts |
Vasculature- capilaries. | Angioblasts |
Connective tissue-collagen | Fibroblasts |
Elastic protein found in connective tissue. Allows tissues to retain their shape after stretching. | Elastin |
First collagen to appear in wound healing. found in immature scars. More prevalent in newborns. | Collagen Type 3 |
Assembled into thin supporting filaments and the predominant collagen type found in cartilaginous tissue. | Type 2 collagen |
Vitamin C | Ascorbic acid |
Healing that occurs when a clean laceration or sterile surgical wound that has orderly healing. | First intention healing |
Temporary make-shift structure. Vascularized connective tissue composed of macrophages, myoblasts, fibroblasts, angioblasts. | Granulation Tissue |
Large and infected wounds. Occurs when wound edges cannot be approximated. Granulation tissue is exposed. | Secondary intention healing |
Elevated but do not grow beyond the original margins of the scar. | Hypertrophic scar |
Activates fibroblasts and macrophages | Platelet derived growth factor |
Required for wound repair and angiogenesis | Fibroblast growth factor |
The formation of new blood vessels | Angiogenesis |
The presence of 2 conditions in a patient | Comorbidity |
Characterized by: formation of a hematoma, necrosis of cells, start of the inflammatory response. Inflammatory phase begins once the blood clot forms. | Degeneration phase healing |
Vascular and cellular response. Vasodilation, increased permeability. Presence of leukocytes, monocytes. | Inflammatory phase |
Collagen and matrix being produced in random patterns | Proliferative phase |
Collagen more organized. Type 3 turns into type 1 collagen. Blood vessels restored. | Maturation- remodeling phase |
Large scar formation. typically seen in burns. | Tissue contracture |