L12 LOCO
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16 questions
| 🇬🇧 | 🇬🇧 |
| METABOLIC MYOPATHIES :vacuolation at periphery of muscle fibre & prominent subsarcolemmal clumping of abnormal mitochondria &‘Ragged red’ fibres | Mitochondrial myopathies |
| Symptoms usually < 6 years fatigu ,Mental retardation ,Muscle weakness ,Frequent falls & difficulty in walking Type 1 fibre predominance | Muscular dystrophies |
| Dysferlinopathy and splitting fibers indicate | Limb girdle muscular dystrophy |
| Duchenne-Becker dystroph caused by | Absence of dystrophin |
| Localized injury to nerve - Axon distal to the injury will rapidly degenerate & -Proximal segment regenerates | Wallerian degeneration |
| Injury to the myelin sheath with preservation of axons cause | Segmental demyelination |
| Generalized injuries to nerve cell bodies or axons,Axonal degeneration starts in more distal part of the axon and progressively extend to the proximal parts | Distal axonal degeneration |
| Most common hereditary peripheral neuropathy | Charcot-Marie Tooth (CMT) disease |
| Distal muscle weakness, atrophy of the calf at Childhood & Autosomal dominant | Hereditary Motor and Sensory Neuropathies |
| Caused by Repeated segmental demyelination and remyelination | Schwannian “Onion-Bulb” Proliferation |
| Malignant Neoplasms of peripheral nerves composed of spindle shaped cells. Mitosis are increased ,Necrosis of tumour is common | Malignant peripheral nerve sheath tumour |