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level: Lecture 14: Inflammatory Myopathies

Questions and Answers List

level questions: Lecture 14: Inflammatory Myopathies

Question	Answer
What are Inflammatory Myopathies?	A group of acquired (and potentially treatable) causes of skeletal muscle weakness
Name 2 Inflammatory Myopathies.	Polymyositis (PM). Dermatomyositis (DM).  Inclusion Body Myositis (IBM).
Out of the 3 Inflammatory Myopathies, which one CAN have an asymmetrical pattern? Polymyositis (PM). Dermatomyositis (DM).  Inclusion Body Myositis (IBM).	Inclusion Body Myotitis
Patients suffering from Inflammatory Mypoathies suffer from proximal muscle weakness. Which muscle pattern in the image indicates the proximal muscles?	A. These patients would have difficulty doing things requiring forward lifting of their limbs, such as climbing stairs, brushing their hair or teeth, getting up out of a chair, lifting objects.
Fine motor movements that depends on the strength of distal muscles, such as buttoning a shirt, sewing, or writing, are affected only LATE in the course of two of the Inflammatory Myopathies, but early in in another. Which of the three IMs sees EARLY issues with fine motor movements?	Inclusion Body Myositis.
True or false: The fine motor movements of the ocular muscles are spared even in advanced cases of Inflammatory Myopathies; if involved, you should question the diagnosis of IMs.	True.
True or False: In all forms of Inflammatory Myopathies, pharyngeal and neck flexor muscles are often involved, causing dysphagia or difficulty in holding up the head (head drop), even if those muscles are not considered part of the distal muscle group affected by IMs.	True
Weakness in two IMs progress subacutely over a period of weeks or months. Which two?	Polymyositis (PM). Dermatomyositis (DM).
Which one of the Inflammatory Myopathies progresses slowly over several years?	Inclusion Body Myositis (IBM).
One of the Inflammatory Myopathies has significantly more symptoms and complications associated with it, such as cardiac disturbances, gastrointestinal issues, dysphagia (speech degeneration), joint contracture and malaise. Which one is it?	Inclusion Body Myositis
Which of Inflammatory Myopathies has the clinical symptoms of a heliotrope rash, Gottron's Sign and a red, erythmic rash on particular parts of the body (shoulder, elbows, back, etc). They may also have dry hands.	Dermatomyositis. Derma refers to the skin, which is appropriate due to the large amount or rashes.
What is a heliotropic rash (heliotrope rash)? Yes, it's a rash, but what's so special about it? Which Inflammatory Myopathy has a heliotrope rash as a symptom?	Dermatomyotitis. A heliotrope rash is a PURPLEish facial rash, named after the purple heliotrope flower (depicted).
This Inflammatory Myopathy mimics other myopathies. This is the diagnosis for patients who DO NOT have ANY of the following: - Rash. - Involvement of extraocular and facial muscle. - Family history of a neuromuscular disease.	Polymyositis
This inflammatory myopathy alone is rare, and is associated with a systemic autoimmune or connective tissue disease, or with a viral or bacterial infection.	Polymyositis
Name 2 symptoms (or symptom areas) of Body Inclusion Myositis.	1) Systemic symptoms: fever, malaise, weight loss, arthragia and Raynaud`s phenomenon 2) Joint Contracture 3) Cardiac issues 4) Gastrointestinal 5) Dysphagia 6) Pulmonary dysfunction (like pneumonia or lung disease) 7) Subcutaneous calcifications, 8)  7) Arthralgia, synovitis (joint pain)
One inflammatory myopathy is more associated with cancers than the others. Which one?	Dermatomyotitis I.e.) - Ovarian cancer. - Breast cancer. - Melanoma. - Colon cancer. - Non – Hodgkin lymphoma.
It is believed that inflammatory myopathies are __________ in etiology.	autoimmune