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level: Generic and Brand Names- Mechanism of Action

Questions and Answers List

level questions: Generic and Brand Names- Mechanism of Action

Question	Answer
Competes with free histamines for binding at H1 receptors, suppressing flare edema and puritis resultant of histamic reaction in the GI, uterus, blood vessels and bronchial muscles	Diphenhydramine-Hydrochloride(Benadryl)
Acts on alpha and beta receptors in the respiratory tract causing vasoconstriction, reducing tissue hyperemia, edema and relaxing bronchial smooth muscle. Also used to treat urinary incontinence by way of alpha adrenergic reaction.	Pseudophedrine-Hyrdrochloride(Sudafed)
Decreases pulmonary secretion viscosity by breaking down disulfide links that bind glyco-proteins in mucus. Also reduces liver damage in acetaminophen toxicity by linking with metabolites that would otherwise bind with and kill liver cells.	Acetylcysteine(Mucomyst)
Suppresses and treats symptoms of cough by thinning bronchial secretions to ease expectoration. Improves efficacy of mucociliary mechanism by removing secretions in the upper and lower airway.	Guaifenesin(Robitussin)
Attaches to beta2 receptors on bronchial cell membranes, stimulating intra-cellular enzyme adenylate cyclase(AC) to convert into adenosine monophosphate(AMP). This relaxes smooth muscle cells and inhibits histamine release.	Albuterol-Sulfate(Proventil)
Decreases activity and number of cells involved in the inflammatory response of rhinitis, asthma and allergies. May inhibit production of chemical mediators such as cytokines, eicosanoids, histamine and leukotrienes. May produce smooth muscle cell relaxation and decreased airway hyper-response.	Beclomethasone(QVAR)
Blocks acetylcholine released from cholinergic fibers from attaching to muscarine receptors on smooth muscle cell membranes, relaxing smooth muscles and causing bronchodilation.	Ipratropium-Bromide(Atrovent)