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Index
»
PHARM 24
»
COMPLEXATION
»
Level 2
level: Level 2
Questions and Answers List
level questions: Level 2
Question
Answer
• Group of metal ion complexes in which a substance provides two or more donor groups to combine with a metal ion
Chelates (B)
What are the 2 classes of complexes?
• Metal ion complexes • Organic molecular complexes
What are the classification of complexes?
• Metal ions complexes • Organic Molecular complexes • Inclusion/Occlusion compounds
under Metal Ion Complexes
• Inorganic type • Chelates • Olefin type • Aromatic type
under Organic Molecular Complexes
• Quinhydrone type • Picric acid type • Caffeine and other drug complexes • Polymer type
under Inclusion/Occlusion Compounds
• Channel lattice type • Layer type • Clathrates • Monomolecular type • Macromolecular type
• Metal ion constitutes the central atom and interacts with a base (electron-pair donor, ligand) • This type of interaction leads to the formation of coordination bonds between the species
Metal Complexes
Metal Ion Complexes in which • The ligand provides only one site for binding with metal
Inorganic type
• Within a ligand, the atom that is directly bonded to the metal atom/ion is called
donor atom
it is a covalent bond in which one atom supplies both electrons
coordinate covalent bond
• If the coordination complex carries a net charge, the complex is called
a complex ion
• Compounds that contain a coordination complex are called
coordination compounds
is the number of donor atoms bonded to the central metal atom/ion
coordination number
• Group of metal ion complexes in which a substance provides two or more donor groups to combine with a metal ion
Chelates (B)
is a molecule called a chelating agent
• EDTA
a claw-like substance that can grab and stick to other molecules
chelating agent
What are the Natural Chelating Agents?
• Chlorophyll • Haemoglobin • Albumin
• The formation or presence of two or more separate coordinate bonds between a polydentate (multiple bonded) ligand and a single central atom
Chelation
2 geometric forms of Chelation
• Cis isomer • Trans isomer (opposite sides)