| TYPES OF TABLETS | 1 Compressed Tablets
2 Multiply Compressed Tablets
3 Sugarcoated tablets
4 Film Coated Tablets
5 Gelatin-coated Tablets
6 Enteric-coated Tablets
7 Buccal and Sublingual Tablets
8 Chewable Tablets
9 Effervescent Tablets
10 Molded Tablets
11 Tablet Triturates, 12 Hypodermic Tablets
13 Dispensing Tablets
14 Immediate Release Tablets
15 Extended Release Tablets
16 Vaginal Tablets, 17 Dissolving Tablets |
| ADVANTAGES OF TABLETS | 1 Large scale production at lowest
cost
2 Easiest and cheapest to package
and ship
3 High stability
4 Easy to handle
5 Lightest and most compact
6 Greatest dose precision and least variability
7 Coating can mark unpleasant taste and improve patient acceptability |
| 1 add the necessary bulk to a formulation to prepare
tablets of the desired size
2 promote adhesion of the particles of the formulation, allowing a granulation to be prepared and maintaining the integrity of the final tablet.
3 which promote breakup of the tablets after
administration to smaller particles for ready
drug availability | 1 Diluents or fillers
2 Binders or adhesives
3 Disintegrants or disintegrating agents |
| 1 which enhance the flow of the material into the tablet dies, minimize wear of the punches and dies, prevent fill material from sticking to the punches and dies, and produce tablets with a sheen
2 such as colorants
and flavorants. | 1 Antiadherents, glidants, lubricants, or
lubricating agents
2 Miscellaneous adjuncts |
| 1 are prepared
by subjecting the fill material to more than a
single compression.
2 may be coated with a
colored or an uncolored sugar later | 1 Multiply compressed tablets
2 SUGARCOATED TABLETS |
| 1 Purpose of sugarcoat
2 Disadvantage of sugarcoat | 1
- Protection from environment
- enhance appearance; permits imprinting
2
-time and expertise required
-may add 50% to the weight
and bulk of the uncoated tablet. |
| 1 compressed tablets
coated with a thin layer of a polymer
capable of forming a skin-like film.
2 A recent innovation; capsule-shaped compressed tablet that
allows the coated product to be about one-third smaller than a capsule filled with an equivalent amount of powder | 1 FILM-COATED TABLETS
2 GELATIN-COATED TABLETS |
| 1 Gelatin-Coated innovator product
2 Gelatin-Coated compared to unsealed tablets | 1 gelcap
2
-more tamper evident
Ex. Tylenol Cold MultiSymptom Daytime
(McNeil Consumer) |
| 1 have delayed-release features. designed to pass unchanged through the stomach to the intestines
2 are flat, oval tablets intended to be dissolved in the
buccal pouch or beneath the tongue
3 disc-shaped solid dosage forms containing a medicinal agent and generally a flavoring substance in a
hard candy or sugar base. | 1 ENTERIC-COATED TABLETS
2 BUCCAL AND SUBLINGUAL TABLETS
3 Lozenges or troches |
| 1 have a smooth, rapid disintegration when chewed or
allowed to dissolve in the mouth, have a creamy base, usually of specially flavored and colored mannitol .
2 are prepared by compressing granular effervescent salts that
release gas when in contact with water
3 can assist in breaking up the tablets and enhancing the dissolution of the active drug | 1 CHEWABLE TABLETS
2 EFFERVESCENT TABLETS
3 “bubble action” |
| 1 may be prepared by molding rather than by compression. The resultant tablets are very soft and soluble and are
designed for rapid dissolution
2 small, usually cylindrical. Molded or compressed tablets
containing small amounts of usually potent drugs | 1 MOLDED TABLETS
2 TABLET TRITURATES |
| 1 Diluents of tablet triturates
2 tablet triturates used sublingually
3 Pharmacists also employ it in compounding | 1 sucrose and lactose
2 nitroglycerin tablets
3 tablet triturates |
| 1 no longer available in the United States.
2 Why hypodermic tablets are eliminated | 1 HYPODERMIC TABLETS
2
-difficulty achieving sterility
-availability of prefabricated injected products |
| 1 are no longer in use; contained large amounts of
highly potent drug substances; highly toxic if taken orally
by mistake
2 are designed to disintegrate and release their medication
with no special rate-controlling features | 1 DISPENSING TABLETS
2 IMMEDIATE-RELEASE TABLETS |
| 1 Dispensing tablets are termed as __
2 The medicaments commonly incorporated
in dispensing tablets: | 1 compounding tablets
2
-mild silver proteinate,
-bichloride of mercury
-merbromin and
-quaternary ammonium compounds |
| 1 are designed to release their medication in a predetermined
manner over an extended period
2 uncoated, bullet-shaped or ovoid tablets
inserted into the vagina for local effects. | 1 EXTENDED-RELEASE TABLETS
2 Vaginal tablets (vaginal inserts) |
| 1 Vaginal tablets contain | 1 Antibacterials (vaginitis caused by Haemophilus vaginalis)
2 Antifungals (vulvovaginitis candidiasis caused by Candida albicans) |
| 1 are characterized by disintegrating or dissolving in the mouth
within 1 minute, some within 10 seconds | 1 Instant-release tablets (rapidly dissolving
tablets, or RTDs) |
| 1 Instant-release tablets disadvantages
2 A number of techniques are used to prepare
these DISSOLVING TABLETS | 1
✓ Drug loading
✓ Taste masking
✓ Friability
✓ Manufacturing costs
✓ Stability of the product
2
✓ Lyophilization
✓ Soft direct compression |
