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level: Level 2

Questions and Answers List

level questions: Level 2

Question	Answer
The physical features of compressed tablets	✓ Round, oblong or unique in shape ✓ Thick or thin ✓ Large or small in diameter ✓ Flat or convex ✓ Unscored or scored in halves, thirds, or quadrants ✓ Engraved or imprinted with an identifying symbol and/or code number ✓ Coated or uncoated ✓ Colored or uncolored ✓ One, two, or three layered
1 Tablet diameters and shapes are determined by 2 The less concave the punches, 3 The more concave the punches,	1 die and punches used in compression 2 the flatter 3 the more convex
1 The quantity of fill in the die of a tablet press determines the __ 2 The volume of fill is adjusted with the first few tablets to yield __ 3 the requirements for content uniformity are met if the amount of active ingredient in each dosage unit lies within the range of __ of the label claim and the standard deviation is __ 4 The degree of pressure affects not only thickness but also __. also the more important criterion since it can affect disintegration and dissolution	1 weight of the tablet 2 desired weight and content 3) 85% to 115%, less than 6% 4 HARDNESS
1 put the tablet between two anvils and read its thickness by scale. It is measured in __ 2 the tablet is put between two jaws of Vernier caliper and measures the thickness of the tablet by reading scare. It is measured in __ 3 The greater the pressure applied, __	1 micrometers (mm) 2 centimeter (cm) 3 the harder the tablets
1 used to measure the degree of force (in kg, pounds, or in arbitrary units) required to break a tablet 2 minimum requirement for a satisfactory tablet 3 A tablet’s durability: may be determined through the use of a	1 Special dedicated hardness testers or multifunctional systems 2 force of about 4 kg 3 friabilator
1 The resistance of a substance to plastic deformation when a pressure is applied on it 2 The condition of being easily crumbled	1 Hardness 2 Friability
1 important for tablets containing medicinal agents (such as antacids and antidiarrheals) that are not intended to be absorbed but rather to act locally within the GI tract. 2 Tablets must disintegrate within the times set in the individual monograph, usually __, but varying from 3) __ for nitroglycerin 4) __ for buccal tablets	1 Tablet disintegration 2) 30 minutes 3) 2 minutes 4) up to 4 hours
allow differentiation between formulations and correlations identifies with in vivo bioavailability data	Dissolution studies in the early stages of a product’s development
Compressed tablets may be made by three basic methods:	✓ Wet granulation ✓ Dry granulation ✓ Direct compression
Most powdered medicinal agents require addition of excipients such as:	✓ Diluents ✓ binders ✓ Disintegrants ✓ Lubricants