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Index
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PHARM DDS
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TABLETS
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Tablet Dissolution Categories
level: Tablet Dissolution Categories
Questions and Answers List
level questions: Tablet Dissolution Categories
Question
Answer
(high-solubility and high-permeability)
Category I
dissolution may be rate-limiting step for absorption and an IVIVC may be expected - dissolution rate is slower than the rate of gastric emptying
Category II
(in the case of a high-solubility and low-permeability) permeability is the rate-controlling step, and only a limited IVIVC may be possible
Category III
(low solubility and low permeability) → significant problems are likely for oral drug delivery
Category IV