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level: DRUGS - LINCOMYCINS

Questions and Answers List

Question	Answer
Used for the treatment of infections caused Staph (osteomylelitis), β-hemolytic strep and pneumococci Non toxic, low incidence for rash, occasionally GI complaints Causes severe diarrhea, Pseudomembranous colitis development	Lincomycin HCL (Lincocin)
One of the most potent agents against non-spore forming anaerobic bacteria, the Bacteroides spp. CAUSES severe diarrhea and PSEUDOMEMBRANEOUS COLITIS (reversible) Its use SHOULD BE RESERVED for staph tissue infections, such as cellulitis and osteomyelitis, pen-allergic pts, severe anaerobic infections outside CNS Replacement of 7(R)-hydroxy group of lincomycin with chlorine 7(S)-chloro-7-deoxylincomycin (Cleocin)	Clindamycin HCl
PSEUDOMEMBRANOUS COLITIS caused by Clindamycin is the result of the overgrowth of __	Clostridium difficile clindamycin-resistant intestinal bacterium
Most powerful bactericidal antibiotics are those that possess a __	Polypeptide Structure
Causes renal toxicity Most powerful bactericidal antibiotics Lack of systemic activity after oral administration They frequently consist of several structurally similar but chemically distinct entities isolated from single source MOST ARE CYCLIC, few exceptions (gramicidins) Frequently contain D-amino acids and/or 'unnatural' AA not found in higher plants or animals Contain non-AA moieties, such as heterocycles, fatty aids, sugars, etc	Polypeptides