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level: SOLVENTS AND VEHICLES FOR INJECTIONS

Questions and Answers List

level questions: SOLVENTS AND VEHICLES FOR INJECTIONS

Question	Answer
- MOST FREQUENTLY USED SOLVENT in the large scale manufacturer of injections - purified by DISTILLATION or by REVERSE OSMOSIS and meets the same standards for presence of total solids - pyrogen-free Use: manufacture of injectable products to be sterilized after preparation.	Water for Injection, USP
not more than 1 mg/100 mL Water for Injection pyrogen free	Purified Water, USP
- single dose container, not larger than 1L - pyrogen free, 0.25 EU/mL - may CONTAIN SLIGHTLY MORE TOTAL SOLIDS than Water for Injection because of the leaching of solids from the glass-lined tanks during sterilization - no antimicrobial agents - use: solvent or diluent for already sterilized and packaged injectable medication.	Sterile Water for Injection, USP
- sterile water for injection CONTAINING ONE OR MORE SUITABLE ANTIMICROBIAL AGENTS - “NOT INTENDED FOR NEONATES” - prefilled syringe, vials NOT MORE THAN 30mL of water - use: only in parenteral administered in small volumes because of the presence of antimicrobial agents (>5ml)	Bacteriostatic Water for Injection, USP
- sterile isotonic solution of NaCl (154mEq/L) in water for injection - use: sterile vehicle in solutions or suspensions of drugs for parenteral administration catheter or intravenous line to infuse fluids & medications to maintain potency Usually, 2 mL is used to flush the line after each use or every 8 hours if the line is not used.	Sodium Chloride Injection, USP
- sterile isotonic solution of NaCl in water for injection - may not be packed larger than 30mL - Use: for bacteriostatic water for injection catheter or intravenous line flush to maintain potency	Bacteriostatic Sodium Chloride Injection
- sterile solutions of NaCl, KCl, and CaCl2 in water for injection - use: vehicle for other drugs/ alone as an electrolyte replenisher and plasma volume expander	Ringer’s Injection, USP
- contains NaCl, KCl, CaCl2 & Na lactate - fluid and electrolyte replenisher and a systemic alkalizer	Lactated Ringer’s Injection