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level: Level 3

Questions and Answers List

Question	Answer
• MOA: forms covalent bond with AChE, but hydrolyzed and released • Effect: like Edrophonium but longer-acting • CA: Myasthenia gravis, antidote for NMB toxicity	NEOSTIGMINE • Prostigmin®
• Like neostigmine, but longer-acting • also used in myasthenia gravis Intermediate-Acting Cholinesterase Inhibitors	PYRIDOSTIGMINE • Mestinon®, Regonol®
• like neostigmine • a natural alkaloid tertiary amine • enters CNS	PHYSOSTIGMINE • Eserine®
•Exelon®	RIVASTIGMINE
• MOA: like neostigmine, BUT RELEASED MORE SLOWLY • Obsolete - was used in glaucoma	Echothiophate
• insecticide • relatively safe for mammals and birds because metabolized by other enzymes to inactive products • some medical use as ECTOPARASITICIDE	Malathion
• Insecticide • Dangerous for all animals • Toxicity is important because of agricultural use and exposure of farm workers	Parathion
• "Nerve gas" • used exclusively in warfare and terrorism	Sarin
Antidote FOR Organophosphate Poisoning:	ATROPINE DIAZEPAM (Reduce convulsion) PRALIDOXIME