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level: Level 4 - Non-Benzodiazepines SH & Melatonin Receptor Agonist

Questions and Answers List

Non-Benzodiazepine Sedatives/Hypnotics and MELATONIN RECEPTOR AGONIST

Question	Answer
• MOA: exhibits a HIGH SELECTIVITY for the α1 subunit of benzodiazepine-binding site on GABAA receptor complex • MOST COMMONLY prescribed drug for INSOMNIA	ZOLPIDEM • Stilnox®
• a "SUPERAGONIST" at BzRs • may be used for patients who tend to be AWAKEN DURING THE NIGHT (for up to 6mos)	ESZOPICLONE
• a SHORT-ACTING nonbenzodiazepine hypnotic • good to INITIATE SLEEP instead of keeping sleep	ZALEPLON • Sonata®
Melatonin Receptors and its effects	• MT1 - sleepiness • MT2 - circadian rhythm • MT3 - IOP
• "HORMONE OF DARKNESS" • PRODUCT OF SEROTONIN found in the pineal gland • biosynthesized and RELEASED AT NIGHT • play a role in the CIRCADIAN RHYTHM of humans	MELATONIN
• effective in INITIATING SLEEP • MORE EFFICACIOUS THAN MELATONIN but LESS EFFICACIOUS than BZD as a HYPNOTIC • approved for the treatment of insomnia	RAMELTEON • Rozerem®