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level: Level 5 (NON SELECTIVE COX INH)

Questions and Answers List

NONSELECTIVE COX INHIBITORS

level questions: Level 5 (NON SELECTIVE COX INH)

QuestionAnswer
Inhibit both COX 1 and COX 2NONSELECTIVE COX INHIBITOR
• a phenylacetic derivative • __ + misoprostol = FOR UPPER GI ULCERATION (can result to diarrhea) • 0.1% ophthalmic preparation - for PREVENTION OF POSTOPERATIVE OPTHALMIC INFLAMMATION • 3% topical gel - FOR SOLAR KERATOSEDICLOFENAC • Cataflam®, Voltaren®
• derived from salicylic acid • effective for CANCER PAIN WITH BONE METASTASES and PAIN CONTROL IN DENTAL (3RD MOLAR) surgery • 2% oral ointment - ANALGESIC FOR PAINFUL ORAL LESIONSDIFLUNISAL • Dolobid®
•a racemic acetic acid derivativeETODOLAC •Lodine®
• a propionic acid derivative • available in TOPICAL OPHTHALMIC formulation for INHIBITION OF INTRAOPERATIVE MIOSIS • IV - for PERIOPERATIVE ANALGESIA in minor ear, neck and nose surgery • Lozenge - FOR SORE THROAT • S/E: COGWHEEL RIGIDITY, ataxia, tremor, myoclonusFLURBIPROFEN
• phenylpropionic acid derivative • lower doses (<2400mg/d) - ANALGESIC ONLY • used in CLOSING PATENT DUCTUS ARTERIOSUS in infants • CONTRAINDICATED to be used concomitantly with ASPIRINIBUPROFEN • Motrin®, Advil®, Nuprin®, Rufen®
• an indole derivative • used for GOUT AND ANKYLOSING SPONDYLITIS • used to ACCELERATE CLOSURE OF PATENT DUCTUS ARTERIOSUS • S/E: at higher doses - PANCREATITIS, psychosis, THROMBOCYTOPENIA, aplastic anemia • PROBENECID PROLONGS ITS HALF-LIFEINDOMETHACIN • Indocin®
prolongs half-life OF INDOMETHACIN ANTI GOUT Used as ENZYME INHIBITORProbenecid
• a propionic acid derivative • can INHIBIT LIPOXYGENASEKETOPROFEN •Orudis®
For SEVERE PAIN • an NSAID promoted for systemic use MAINLY AS ANALGESIC, not as anti-inflammatory drug • may DECREASE OPIOID REQUIREMENT (Narcotic Analgesic)KETOROLAC • Toradol®
• a VERY EXPENSIVE DRUG •the ONLY NONACID NSAID; a ketone •RESEMBLES NAPROXEN in structure PRODRUGNABUMETONE
•a naphthylpropionic acid derivative •used for FEVER ASSOCIATED WITH CANCERNAPROXEN •Naprosyn®