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level: Level 6

Questions and Answers List

NONSELECTIVE COX INHIBITORS PART 2

Question	Answer
•used ONLY AS ANALGESIC	MEFENAMIC ACID •Ponstel®
• a propionic acid derivative •MILDLY URICOSURIC (FOR GOUT) URICOSURIC - Agent to excrete the uric acid from the body through urine	OXAPROZIN •Daypro®
• an oxicam •RISK OF HAVING ULCER is 9.5X HIGHER than other NSAIDs • used for usual RHEUMATIC CONDITIONS	PIROXICAM • Feldene®
• a SULFOXIDE PRODRUG • SUPRESSES FAMILIAL INTESTINAL POLYPOSIS and may INHIBIT DEVELOPMENT OF COLON, BREAST, & PROSTATE CANCER • S/E: SJS (Stevens-Johnson syndrome), thrombocytopenia, agranulocytosis	SULINDAC • Clinoril®
•INEFFECTIVE in the treatment of GOUT •may CAUSE THROMBOCYTOPENIC PURPURA	TOLMETIN •Tolectin®
•used ONLY AS ANALGESIC	MEFENAMIC ACID •Ponstel®
OTHER NSAIDs	•Azapropazone • Carprofen • Meclofenamate • Tenoxicam
•N-acetyl-p-aminophenol (APAP) •MOA: inhibits prostaglandin synthesis in the CNS (analgesic and antipyretic) •LESS EFFECT ON COX in PERIPHERAL TISSUES (due to peripheral inactivation), which accounts for its WEAK ANTI-INFLAMMATORY ACTIVITY (not an NSAID)	ACETAMINOPHEN