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level: Moderate

Questions and Answers List

level questions: Moderate

Question	Answer
Normal hemoglobin levels in males	13.5mg-17.5 mg/dL
Normal hemoglobin levels in females	12.5-16.0 mg/dL
Normocytic MCV values	80-100 um^3
Laboratory measure of iron in the blood	Serum Iron
Laboratory measure of transferrin molecules in the blood	Total Iron-binding capacity
Laboratory percentage of transferrin molecules that are bound by iron	% saturation
normal value of % saturation	33%
reflects iron stores in macrophages and liver	Serum Ferritin
syndrome characterized by iron deficiency anemia with esophageal web and atrophic glossitis	Plummer-Vinson Syndrome
co-factor of Aminolevulinic acid synthethase (ALAS)	vitamin B6
enzyme that catalyzes the conversion of ALA to porphobilinogen	Aminolevulinic acid dehydrogenase (ALAD)
enzyme that attaches protoporphyrin to iron to make heme	Ferrocheletase
chromosome that codes for globin alpha genes	chromosome 16
tetramers of β chains that damage RBCs when 3 alpha genes are deleted	HbH
tetrameres of γ chains that damage RBCs in utero when 4 alpha genes are deleted	Hb Barts
chromosome that codes for globin beta genes	chromosome 11
Folate circulates in the serum in what form?	methyltetrahydrofolate
Methyl THF tranfers its methyl group of what molecule?	Vitamin B12 or Cobalamin
This molecule receives methyl from Vitamin B12	homocysteine
adding methyl to homocystein produces what molecule	methionine
impaired division of granulocytic precursors leads to what kind of neutrophils?	hypersegemented neutrophils
parasite that causes damage to the terminal ileum which may then lead to vitamin B12 deficiency	Diphyllobothrium latum
cofactor tor the conversion of methylmalonic acid to succinyl CoA	Vitamin B12 or Cobalamin
Two main causes of normocytic anemia	peripheral destruction and underproduction
normal reticulocyte count	1-2%
corrected reticulocyte count formula	RC x Hct/45
indicates good marrow response	corrected RC >3%
indicates poor marrow response	corrected RC <3%