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level: Easy

Questions and Answers List

level questions: Easy

Question	Answer
normal WBC count	5-10 K/uL
syndrome caused by developmental failure of the 3rd and 4th pharyngeal pouch	Di George Syndrome
Also known as kissing disease	Infectious Mononucleosis
Most common pathogen in kissing disease	EBV
T-cell hyperplasia in kissing disease occurs in what part of the lymph node	paracortex
T-cell hyperplasia in kissing disease occurs in what part of the spleen?	periarterial lymphatic sheath
Test used for screening of kissing disease	Monospot test
A negative monospot test is suggestive of what kissing diseae etiology?	CMV
Monospot test turns positive within how many weeks after infection?	1 week
What cell is in the picture?	Atypical lymphocyte
Dormancy of virus in B cells leads to an increased risk for recurrence and what?	B-cell lymphoma
defined as the accumulation of >20% blasts n the bone marrow	Leukemia
large immature cells with punched out nucleoli	Blasts
Lymphoblasts have a positive nuclear staining for what?	TdT
Most common type of ALL	B-ALL
usually presents n teenagers as mediastinal (thymic) mass	acute lymphoblastic lymphoma
neoplastic accumulation of myeloblasts (>20%) in the bone marrow	Acute myeloid leukemia
Myeloblasts are usually characterized by positive cytoplasmic staining for what?	Myeloperoxidase (MPO)
Crystal aggregates of MPO may be seen as what?	Auer rods
subtype of AML which involves translocation of the retinoic acid receptor	Acute promyelocytic leukemia
treatment for APL	all-trans-retinoic acid (ATRA)
subtype of AML wherein monoblasts prolferates and usually lacks MPO	Acute monocytic leukemia
subtype of AML wherein megakaryoblasts proliferates and usually lacks MPO	Acute megakaryoblastic anemia
Blasts characteristically inflitrate what part of the body in acute monocytic anemia?	Gums
most common leukemia overall	Chronic Lymphocytic Leukemia (CLL)
Neoplastic proliferation of mature B-cells characterized by hairy cytoplasmic processes	Hairy Cell Leukemia
accumulation of hairy cells occurs in what part of the spleen?	Red pulp
associated with HTLV-1	Adult T-cell Leukemia/Lymphoma (ATLL)
radiologic finding in ATLL	lytic (punched-out) bone lesions
neoplastic proliferation of mature CD4 T-cells in the epidermis	Mycosis fungoides
aggregates of neoplastic cells in the epidermis	Pautrier microabscesses
neoplastic proliferation of mature cells of the myeloid lineage	Myeloproliferative disoders
neoplastic proliferation of mature myeloid cells especially granulocytes and their precursors	Chronic Myeloid Leukemia (CML)
Basophils are characteristically increased in this disease	Chronic Myeloid Leukemia (CML)
What fraction of CML can transform to AML?	two-thirds
What fraction of CML can transform to ALL?	one-third
neoplastic proliferation of mature myeloid cells especially RBCs	Polycythemia Vera (PV)
First line treatment in PV	phlebotomy
second-line treatment in PV	hydroxyurea
neoplastic proliferation of lymphoid cells that forms a mass	Lymphoma
two major types of Lymphoma	Hodgkin Lymphoma (HL) and Non-Hodgkin lymphoma (NHL)
malignant cells of HL	Reed-Sternberg cells
overall frequency of NHL	60%
overall frequency of HL	40%
malignant cells of NHL	Lymphoid cells
age group of NHL	Late adulthood
age group of HL	Young adults
spread of NHL	diffuse; often extranodal
spread of HL	contiguous; rarely extranodal
neoplastic proliferation of small B cells (CD20) that form follicle-like nodules	Follicular lymphoma
neoplastic proliferation of small B cells (CD20) that expands the mantle zone	Mantle cell lymphoma
region immidately adjacent to lymph node follicles	Mantle zone
neoplastic proliferaton of small B cells (CD20) that expands the marginal zone	Marignal zone lymphoma
region immidately adjacent to lymph node mantle zone	Marginal zone
marginal zone lymphoma in mucosal sites	MALToma
neoplastic proliferation of intermediate-sized B cells (CD20) associated with EBV	Burkitt lymphoma
characteristiic finding of Burkitt lymphoma under microscopy	starry-sky apperance
most common form of NHL	Diffuse Large B-cell Lymphoma
neoplastic proliferatoin of large B cells (CD 20) that grow diffusely in sheets	Diffuse Large B-cell Lymphoma
large B cells with multilobed nuclei and prominent nucleoli	Reed-Sternberg cells
most common type of HL	Nodular sclerosis
most common demographics of nodular sclerosis	young adult female
subtype of HL that has the best prognosis	Lymphocyte-rich
this HL subtype is characterized by abundant eosinophiils	Mixed cellularity
most aggressvie subtype of HL usually seen in the elderly and HIV positivie individuals	Lymphocyte-depleted
Malignant proliferation of plasma cells in the bone marrow	Multiple myeloma
Most common primary malignancy of the bone	Multiple myeloma
Most common malignant lesion of the bone overall	Metastasis
Most common cause of death in multiple myeloma	infection
free light chain excreted in the urine of patients with multiple myeloma	Bence Jones protein