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level: Level 4

Questions and Answers List

Question	Answer
minimum effective concentration of drug needed at the receptors to produce the desired pharmacologic effect.	MEC
minimum toxic concentration that will barely produce a toxic effect	MTC
the time required for the drug to reach the MEC	Onset time
is the difference between the onset time and the time for the drug to decline back to MEC	Duration of drug action
The MAXIMUM and MINIMUM drug concentrations achieved during repeated dosing cycles	Peak and trough concentrations
the condition in which the average total amount of drug in the body does not change over multiple dosing cycles (ie, the condition in which the rate of drug elimination equals the rate of administration)	Steady state
the difference between peak drug concentration and MEC	Intensity of pharmacologic effect
is the concentration between MEC and MTC	Therapeutic window
the ratio between the toxic and therapeutic dose.	Therapeutic index
is related to the dose, the rate constant for absorption, and the elimination constant of the drug.	Peak plasma level (Cmax)
is the time of maximum drug concentration in the plasma and is a rough marker of average rate of drug absorption	Time for peak plasma level (Tmax)
relates to the amount of drug absorbed systematically	AUC