What are transmembrane receptors with enzymatic cytosolic domain? | they transduce ligand signal to activation of an enzymatic domain linked to it.
they play a role in cell metabolism, growth and differentiation (EGF -epidermal), PGF...) |
What are the classes of transmembrane receptors with enzymatic cytosolic domain? | Receptor Tyrosine kinase (N-terminus extracellular and C cytosolic, receptors dimerize with ligand binding - becomes active kinase - activates IP3 and MAP kinase in cascade activation (GF usually))
Receptor Tyrosine phosphatase
Tyrosine kinase associated receptor
Receptor serine/threonine kinase
Receptor guanylyl cyclase |
What are intracellular receptors? | For lipophilic molecules, triggering conformational change, transporting the ligand-receptor complex to nucleus, which bind to DNA sequences regulating gene expression (after it becomes dimerized) |
What are extracellular receptors? | Enzymes with active sites located outside the membrane, ACE for example, integral membrane protein in endothelia converting angiotensin I to angiotensin II generating active hormone AngII on vascular smooth muscle action |
What are cell surface adhesion receptors? | They are receptors needed for the adhesive interaction between cells in forming tissues and migration in case of inflammation.
in many cases they combine to form a firm adhesion regulated by intracellular regulators by changing the affinity of their expression and localization on cell surface. |