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Index
 »Â
PHARMA_2F - TOXICOLOGY 1
 »Â
Chapter 1
 »Â
TOXICOLOGY 1 - SOLVENTS
level: TOXICOLOGY 1 - SOLVENTS
Questions and Answers List
level questions: TOXICOLOGY 1 - SOLVENTS
Question
Answer
Widely used as an industrial solvents, degreasing & cleaning agents
Halogenated Aliphatic Hydrocarbons
Carbon tetrachloride
Halogenated Aliphatic Hydrocarbons
Chloroform
Halogenated Aliphatic Hydrocarbons
Trichloroethylene
Halogenated Aliphatic Hydrocarbons
Tetrachloroethylene
Halogenated Aliphatic Hydrocarbons
Clinical effects of Halogenated Aliphatic Hydrocarbons if there is CHRONIC workplace exposure
1. neurotoxicity, 2. peripheral neuropathy
Main clinical effect of this SOLVENT is CNS depression (it is a CNS depressant)
Aromatic Hydrocarbons
250 - 500 ppm of Benzene (Acute Toxic Effect)
vertigo, drowsiness, nausea, headache
3000 ppm of Benzene (Acute Toxic Effect)
euphoria, nausea, locomotor problem, coma
7500 ppm of Benzene (Acute Toxic Effect)
fatal
Chronic exposure to Benzene would cause?
bone marrow injury
Higher levels of chronic exposure to Benzene would cause?
aplastic anemia, pancytopenia, thrombocytopenia
Low levels of Chronic epxposure to Benzene would cause?
leukemia, myeloma, myelodysplastic syndrome
An aromatic hydrocardon which is a CNS depressant, skin/eye irritant & FETOTOXIC
Toluene
An aromatic hydrocarbon which is NOT myelotoxic & NOT leukemia-associated (unlike benzene)
Xylene
Benzene
Aromatic Hydrocardon
Toluene
Aromatic Hydrocardon
Xylene
Aromatic Hydrocardon