adherens junctions transmembrane proteins | Cadherin |
desmosome transmembrane protein | cadherin |
focal adhesion transmembrane protein | integrins |
hemidesmosome transmembrane protein | integrins |
Gap Junction transmembrane protein | connexins |
Tight Junction Transmembrane protein | claudin, occludin |
Adherens junctions adapters | p120, alpha and beta catenin, vanculin |
Desmosome Adapter | plaquin |
Focal Adhesion adapter | talin, kidlin, vinculin |
hemidesmosome adapter | plectin |
Adherens junctions cytoskeletal element | actin |
desmosomes cytoskeletal element | intermediate filament |
focal adhesion cytoskeletal element | actin |
hemidesmosome cytoskeletal element | intermediate filament |
Adherens junctions purpose | cell-cell adhesion |
desmosome purpose | cell-cell adhesion |
focal adhesion | cell-ECM adhesion |
hemidesmosome purpose | cell-ECM adhesion |
gap junction purpose | allow movement between cells |
tight junction purpose | prevent movement between cells |
myosin (I) structure (3) | plus, nonprocessive, 1 head |
myosin (II) structure (3) | plus, nonprocessive, 2 heads |
myosin (V) structure (3) | plus, processive, 2 heads |
myosin (VI) structure (3) | minus, processive, 2 heads |
kinesin structure (3) | plus ended, processive, 2 heads similar to actin |
dynein structure | minus ended, processive, 2 heads, stalk, neck, tail |
myosin ATP binding | release from actin |
myosin ATP hydrolysis | cock head |
myosin ADP release | bind and power stroke |
kinesin ATP binding | power stroke and cocking |
kinesin ATP hydrolysis | release from microtubule |
kinesin ADP release | caused by binding |
Dynein ATP binding | release and extension |
Dynein ATP hydrolysis | binding and power stroke |
Cap Z | binds plus end of actin, prevents addition |
Tropomodulin | binds minus end, prevents removal |
Tropomyosin | stabilizes actin fibers |
Cofilin | forces actin fiber breakdown |
Thymosin | binds actin monomer, prevents addition |
profilin | binds actin monomer increasing addition |
G-actin | monomer for actin |
F-actin | polymer for actin |
formin | works with profilin, stabilizes G-actin, increases addition |
microtubule monomers | alpha and beta tubulin |
gamma tubulin | removes nucleation, place for dimers to add to |
Microtubule GTPase | beta tubulin |
Kinesin-13 | slows addition, enduces catastrophe, destabilization of protofillament |
XMAP215 | increases growth, slows catastrophe, stabilization of protofillament |
Cillia/Flagella | microtubules 9+2 |
centrioles | microtubules 9+0 |
microtubule protofillaments per tubule | 13 |
Keratin (I& II) | acid and base, give strength to epithelium, provide structure for hair, fingernails, scales |
Vimentin III) | widely expressed, creates junctions with other cells, involved in cell signalling |
Neurofilaments (IV) | help axon grow and strengthen it |
Lamins (V) | in nucleus, can make a meshwork |
Nestin (VI) | in axons, regulate axon width |