Explain the neurotransmission at the skeletal muscle endplate is fast, direct and always excitatory

Presynaptic response to skeletal muscle: Skeletal muscle cells express a single type of receptor in the endplate, nAChR channels, in high density (high safety factor) Endplate potential dysfunction is related to:  Myasthenia gravis–an autoimmune disease Muscle EPPs in myasthenia gravis lack the safety factor, leading to weakness of voluntary muscles Neostigmine and other inhibitors of ACh esterase are used to treat patients with myasthenia gravis.