How does the local inflammatory response of the PMs become the systemic inflammatory response?

1. the macrophages produce granulocyte macrophage colony-stimulating factor (GM-CSF) and IL-1beta, which both stimulate the leukocyte production and release from the bone marrow 2. the macrophages also produce IL-6, which stimulate the liver hepatocytes, leading to a production of C-reactive protein, fibrinogen and antiproteases. it also increases the production of platelets.