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From course:

BBS2001 Threats and Defence Mechanisms

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Question:

How do naive T cells migrate into the lymph nodes?

Author: Mirte Schattorie



Answer:

1. rolling adhesion on high endothelial venules (HEVs) mediated by L-selectin 2. chemokines (CCL19, CCL21) from lymph node attach to CCR7 on the T cell 3. CCR7 activates leukocyte function-associated antigen 1 (LFA-1) on the T cell 4. binding affinity of LFA-1 to ligand ICAM-1 on endothelium is increased 5. firm binding 6. T cell exists the vessel through junctions into the lymph node


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