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BBS2001 Threats and Defence Mechanisms
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Question:
How do naive T cells migrate into the lymph nodes?
Author: Mirte SchattorieAnswer:
1. rolling adhesion on high endothelial venules (HEVs) mediated by L-selectin 2. chemokines (CCL19, CCL21) from lymph node attach to CCR7 on the T cell 3. CCR7 activates leukocyte function-associated antigen 1 (LFA-1) on the T cell 4. binding affinity of LFA-1 to ligand ICAM-1 on endothelium is increased 5. firm binding 6. T cell exists the vessel through junctions into the lymph node
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