How do ACE inhibitors work

Drugs which inhibit the action of angiotensin converting enzyme are important in the treatment of heart failure Prevent the conversion of angiotensin I to angiotensin II Decrease vasomotor tone ( blood pressure is reduced ) Reduced afterload of the heart Decrease fluid retention so there is decrease in blood volume Reduce preload of the heart Reduce work load of the heart Angiotensin II receptor blockers (ARBs) have similar effects e.g. losartan