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Drugs on the CVS

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Question:

What are some factors that induce negative lusitropy

Author: Lapras Fan



Answer:

High cytoplasmic calcium SERCA not working properly Alkalosis Increased affinity of troponin C Cardiac glycosides --> cardiac glycosides inhibit the Na+‐K+‐ATPase on cardiac and other tissues, causing intracellular retention of Na+, followed by increased intracellular Ca2+ concentrations


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