Addisons disease

Destruction of entire adrenal cortex • Deficiency of all hormones • Mineralocorticoids • Glucocorticoids • Sex steroids Clinical features • Weight loss • Anorexia • Malaise • Weakness • Fever • Depression , amenorrhoea, low libido, abdominal pain, myalgia, arthalgia, nausea. Specific clinical features: Pigmentation ACTH, Postural hypotension mineralocorticoid, 90% presentations. Biochemical features: Low sodium, high potassium, high urea, low glucose.