Emphysema (em-fu-see-muh)

- Caused by smoking or air pollution - Particles trapped in alveoli - Causes inflammation - Attracts phagocytes, produces enzymes, breaks down elastin, protein in walls of alveoli - Alveoli cannot recoil + expel air - Alveoli die, reducing SA, reducing gas exchange - Increases PVR - Shortness of breath, wheezing