Red Cell Development

Primitive red cells develop in the blood isles of the yolk sac. First immune cells in AGM. Cells populate the foetal liver and thymus to make first mature RBS. In adults happens in RBM. Spleen removes old RBC. Goes from HSC-MP-CMP-MEP-RBC. Mediated by factors GATA2-GATA1. Cytokines SCF, TPO- IL-3, TPO-EPO. EPO important regulator of RBC production