PERK is also a stress sensor. PERK vs IRE1

Share similarities: The ER domains of PERK and IRE1 share sequence and structural similarity (from yeast and mammals). The cytosolic portion of PERK and IRE1 both possess kinase domains that autophosphorylate in trans. Display differences: IRE1 activation leads to specific splicing and production of transactivators of transcription. However, PERK activation leads to interference with translation.