How do we map a disease locus?

Recombination occurs between homologous chromosomes during meiosis. Produces gametes with new combinations of parental alleles. Independent assortment of different chromosomes – 50:50 chance of which of the pair of parental chromosomes are inherited. Look for co-segregation of the disease with genetic markers. The more individuals sampled the more recombinations separate unlinked genetic markers from the disease locus