Hormonal Methods: 2: Patches that slowly but continuously release a combination of estrogen and progesterone. After the patch-free week, a new cycle of 3 weeks on, 1 week off begins again. Less effective in women who are obese not be placed on any area where makeup, lotions, or creams will be applied; at the waist where bending might loosen the patch; or anywhere the skin is red, irritated, or has an open lesion. can be worn in shower, while bathing, or swimming. If a patch does come loose, the woman should remove it and immediately replace it with a new patch. Mild breast discomfort and irritation at site may occur.