Adverse Reactions to Anti-infective therapy: 5: • anti- infective causes at times destruction of the normal flora thus opportunistic pathogens have the opportunity to invade tissues and cause infections. • - common superinfections include vaginal or GI yeast infections, proteus and pseudomonas which are a result of broad spectrum antibiotic use. • - pt.’s should be monitored closely and appropriate treatment should be started as soon as possible.