First-Generation Cephalosporins: Dosage/Route: Adult: 1-2 g PO in a single or two divided doses; reduce dose in renal impariment Pediatric: 30 mg/kg/d PO in divided doses q12h usual indications: Treatment of UTIs, pharyngitis, and tonsilitis caused by group A beta-hemolytic stretptococci, as well as skin infections.