Second-Generation Cephalosporins: Dosage/Route: Adult: 1-2 g IM or IV q6-8h; reduce dose with renal impairment Pediatric: 80-160 mg/kg/d IM or IV in divided doses q4-6h Usual Indications: Treatment of sever infections; preoperative prophylaxis for cesarean section and abdominal, vaginal, biliary or colorectal surgery; more effective in gynecological and intra-abdominal infections than some other agents.