Third-Generation Cephalosporins: Dosage/Route: Adult: 1-2 g/d IM or IV in divided doses b.i.d.-q.i.d. Pediatric: 50-75 mg/kg/d IV or IM in divided doses q12h Usual Indications: Treatment of moderate to severe skin, urinary tract, and respiratory tract infections; pelvic inflammatory disease; intra-abdominal infections; peritonitis; septicemia; bone infections; CNS infections; preoperative prophylaxis; off-label use for treatment of Lyme disease.