PHARM MED ORG: SAR OF QUINOLONES
1 Study shows that __ moiety is essential for antibacterial activity

2 The __ must be annulated with aromatic ring

3 Isosteric replacements of __ for carbon atoms at positions __ leads to retention of antibacterial activity

4 Introduction of substituents at position __ greatly reduces or abolishes activity
But substitutions at position __ at annulated ring produce good effects

5) __ group at position C5 increases activity

6) __ substitution at position 6 significantly enhance activity

7) __ substitution at position 1 is essential for activity

Question

SAR OF QUINOLONES 
1 Study shows that __ moiety is essential for antibacterial activity

2 The __ must be annulated with aromatic ring

3 Isosteric replacements of __ for carbon atoms at positions __ leads to retention of antibacterial activity

4 Introduction of substituents at position __ greatly reduces or abolishes activity
But substitutions at position __ at annulated ring produce good effects

5) __ group at position C5 increases activity

6) __ substitution at position 6 significantly enhance activity

7) __ substitution at position 1 is essential for activity

Dwight Obillos · Accepted Answer

1) 1,4-dihydro-4-oxo-3-pyridinecarboxylic acid

2 Pyridone system

3 Nitrogen,

2,5,6 and 8

4) 2,

5,6,7 and 8

5) Amino

6) Fluorine
7) Alkyl substitution

PHARM MED ORG

1) 1,4-dihydro-4-oxo-3-pyridinecarboxylic acid 2 Pyridone system 3 Nitrogen, 2,5,6 and 8 4) 2, 5,6,7 and 8 5) Amino 6) Fluorine 7) Alkyl substitution

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