Question:
What are the methods of Bacterial Resistance in Beta lactam type of drugs?
Author: LEIGHTON DWIGHT OBILLOSAnswer:
1 Efflux pumps 2 Beta-lactamases enzyme hydrolyze the amide bond of Beta-lactam ring (Inactivation) 3 Mutation of genes, altering the active sites and production of PBPs (penicillin binding proteins) 4 Closure of Porins 5 Impaired penetration of drug to target PBPs
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