Antibacterial activity against Gram POSITIVE > staph, strep, enterococci, Clostridium, Corynebacterium spp, Propionibacterium acnes and L. monocytogenes Mixture of five closely related glycopeptide antibiotic Actinomycete Actinoplanes teichomyceticus Greater lipid solubility than vancomycin Long half life- Once a day dosing Not irritating to tissues>IM or IV Same MOA, less toxic than vancomycin