Question:
Barbiturates MOA
Author: LEIGHTON DWIGHT OBILLOSAnswer:
1 Bind to GABA a Receptor at different allosteric sites 2 Facilitates GABA action 3 Barbiturates increase DURATION of OPENING of the Chloride channels 4 Membrane HYPERPOLARIZATION (decrease in cell excitability) 5 CNS Depression
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Author
LEIGHTON DWIGHT OBILLOS