Neurotransmission at adrenergic neurons process

1 Tyrosine is hydroxylated into Dihydroxyphenylalanine (DOPA) by Tyrosine Hydroxylase. It is then converted to Dopamine by Aromatic l-amino acid decarboxylase in the presynaptic neurons 2 Dopamine is transported to vesicles. Dopamine is hydroxylated to form Norepinephrine. 3 Influx of Ca2+ causes vesicle to fuse with cell membrane and undergo EXOCYTOSIS. 4 Norepinephrine binds to Post synaptic receptor 5 Norepinephrine diffuses out of synaptic space and go to systemic circulation. or turned inactive metabolite by catechol-O methyltransferase or REUPTAKE back to the Neuron 6 Methylated by COMT and oxidized by MAO