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Endocrinology

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Question:

How is the pathophysiology of 21-hydroxylase deficiency?

Author: H K



Answer:

Decrease in aldosterone and cortisol production, increase in ACTH, adrenal hyperplasia, and accumulate 17-OH-Progesterone which will eventually give delta 4 androstendione and testosterone This leads to hypotension, hyperkalemia and loss of water (no aldosterone) and hyponatremia.


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Author

H K
H K