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Endocrinology

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Question:

How is the pathogenesis of DKA?

Author: H K



Answer:

When Insulin is completely blocked, it will cause glucopenia in cells (lack of glucose) so we have more gluconeogenesis and glycogenolysis causing hyperglycemia, and thus osmotic diuresis. In parallel we have use of other energy source which is lipolysis, which will give free fatty acids that will get oxidized into ketone eventually.


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Author

H K
H K