Ampules - Since air or fluid may now pass freely in and out of the container, it is not necessary to replace the volume or fluid to be withdrawn with air. - Before an ampule is opened, any solution visible in the top portion (head) should be moved to the bottom (body) by swirling the ampule in an upright position, tapping the ampule with your finger or inverting the ampule and then quickly swinging it into an upright position.