How to proteins accumulate intracellular?

Less common than fat accumulation, in kidney nephrotic syndrome causes heavy protein leakage of glomerular filter thus increased reabsorption (of albumin) giving pink hyaline cytoplasmic droplets in cells of proximal tubule If it persists, proteinuria abates (decreases) Another example is Igs accumulate in RER of plasma cells forming eosinophilic Russel bodies