How is the pathophysiology of PE?

Deep venous thrombus of lower extremity (usually) (mostly iliofemoral veins) 50-80% originate below popliteal vein and propagate proximally, or within proximal veins Most calf vein thrombi resolve spontaneously only 20% go into proximal veins Thrombus travel to lungs may lodge to bifurcation of pulmonary artery cause hemodynamic compromise Smaller thrombi may go more distally and cause pleuritic chest pain by initiating inflammatory response