How is the pathophysiology of osteoporosis?

Bone is remodeled by osteoclasts and osteoblasts (equilibrium), till puberty osteoblast activity predominates and at puberty there is more bone formation by sex hormones then just after puberty both blast and clast are equal After 30 years of age clast predominates decreasing bone mass, in addition females at menopause decrease estrogen and thus decrease bone formation leading to more osteoporosis as estrogen def decreases osteoblast activity and increase osteoclast activity, in addition to indirect effect by causing secondary hyperparathyroidism in collab with decreased Ca2+ intake)