What is hypercortisolism?

Can be ACTH dependent (Cushing's syndrome) or Independent Cushing's syndrome caused by: pituitary adenoma (Cushing's disease - 70%), Ectopic ACTH production (SCLC - 10%), CRH ectopic secretion ACTH independent Cushing's syndrome: Either by primary adrenal secretion or exogenous admin, due to adenoma (10%) carcinoma (8%), bilateral micronodular adrenal hyperplasia (Carney syndrome: Schwanoma, testicular, vertebral, skin lesions in addition to adrenal hyperplasia, familial or sporadic)) Massive macronodular adrenal hyperplasia (Fasicular zone excess receptor formation - GIP, LH, AVP) Exogenous admin of cortisone (inactive cortisol- activated by B HSD 2 enzyme)