Question:
What are the clinical manifestations of primary hyperaldosteronism?
Author: H KAnswer:
HTN (variable degree, not obligatory) Hypokalemia (Severe with hyperkaliuria, but 20% have normal potassium) Moderate Hypervolemia (Due to increased water absorption in distal tubule) Metabolic acidosis (Na+ retension, H+ and K+ excretion) Due to HTN (headache, retinopathy -rare) Due to hypokalemia and acidosis (neuromuscular symptoms,DI, ECG disorder, orthostatic HTN, glucose intolerance... Due to aldosterone action on CV (cardiac hypertrophy/fibrosis, vascular muscular hypertrophy
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