DRUG DISCOVERY DEVELOPMENT (DDD): SMALL NUMBER of HEALTHY INDIVIDUALS

To assess the compound’s SAFETY

Life-threatening disease (AIDS, cancer)- SICK IND. MAY BE ENROLLED

STARTING DOSE IS LOW (1/10 of the highest no-effect dose)

Preliminary ADME (parent drugs and metabolites)

P’KINETICS AND PCOL EFFECTS are OBTAINED

Question

SMALL NUMBER of HEALTHY INDIVIDUALS

To assess the compound’s SAFETY

Life-threatening disease (AIDS, cancer)- SICK IND. MAY BE ENROLLED

STARTING DOSE IS LOW (1/10 of the highest no-effect dose)

Preliminary ADME (parent drugs and metabolites)

P’KINETICS AND PCOL EFFECTS are OBTAINED

LEIGHTON DWIGHT OBILLOS · Accepted Answer

Phase 1 clinical trials

SMALL NUMBER of HEALTHY INDIVIDUALS To assess the compound’s SAFETY Life-threatening disease (AIDS, cancer)- SICK IND. MAY BE ENROLLED STARTING DOSE IS LOW (1/10 of the highest no-effect dose) Preliminary ADME (parent drugs and metabolites) P’KINETICS AND PCOL EFFECTS are OBTAINED